Platelets: Production, Function, Transfusion, and Storage
نویسنده
چکیده
Still another attractive book attempting to describe the cause, course, and current treatment of diabetic retinopathy is now available. This particular volume represents papers presented at a Symposium held in 1972. Of course the thinking on the subject of diabetic retinopathy is in a rapidly changing phase, and therefore comments and discussion, even from serious-minded persons, are soon outdated in this field. The editors state in the final paragraph of the preface that their book is not intended to offer final answers, and with this humble beginning they present a series of 20 chapters. It is difficult to comprehend the target audience for this volume. On the assumption that it is intended for medical students, it is too detailed and indefinite. Were it intended for general practitioners and internists, the overwhelming mass of technique and detail precludes its appropriateness for this group. The diabetologists will immediately understand that the ophthalmologist is in the throes of testing new techniques. The ophthalmologists, themselves under pressure to supervise and treat many of these diabetic retinopaths, will be at a loss to decide what to recommend for these patients. The reasons for the latter comments are these. Chapters on the identification of disc feeder vessels, photocoagulation treatment of the macula, and direct treatment of the disc new vessel formation are outdated. Not last within this collection of clinical material are some very fine chapters on basic morphology and physiology. In particular, the chapters on the role of ischemia, retinal blood flow, and pathology of retinal photocoagulation are of extreme importance ot the practitioner and student. Of particular use to the diabetologist and generalist are the wonderful photos of both background and proliferative retinopathy illustrated in chapters 10 and 16. This is a book for persons with special interests in diabetes and, in particular, for those who want to follow closely the evolution of research and treatment for the number one cause of blindness in the United States. In this latter regard, the authors have achieved the hope stated in the preface that "this volume will add to the current store of information and, more importantly, stimulate further research into this major cause of blindness."
منابع مشابه
تاثیر گلیکوزیلاسیون برعملکرد و فاگوسیتوز پلاکت ها در طول نگهداری فرآورده پلاکت کنسانتره در سرما
Background and purpose: Cold storage results in clustering of gpIbα molecules on platelets. Consequently, the lectin domains of αMβ2 receptors on the liver macrophages recognize these molecules and ingest the platelets. Probably coverage of sugar molecules of gpIbα using galactose could prevent the recognition and ingestion of platelets by macrophages. The purpose of this study therby was to...
متن کاملتاثیر فیلتراسیون پیش از ذخیره کردن بر فعال شدن پلاکتها در فراوردههای پلاکتی
Preparation conditions and platelet storage for transfusion may cause platelet activation, which contributes to decreased ability of stored platelet to function and survive in vivo after transfusion compared with that seen with freshly prepared platelets. Using flowcytometry, we investigated platelet membrane expression of CD62P, CD63 in platelet stored for up to 3 days under standard blood ba...
متن کاملThe surface markers and survival rate of platelets during storage at 4°C: The influence of sodium octanoate
Background: Storage of platelet concentrates (PCs) at room temperature (20-24°C) limits its storage time to 5 days due to the destructive effects of platelet storage lesion (PSL) and bacterial contamination. Although prolonged storage of platelets (PLTs) at 4°C reduces the likelihood of bacterial contamination and PSL levels, it is accompanied by an increase in the clearance rate and changes in...
متن کاملمطالعه سطوح بیان گیرندههای چسبندگی پلاکتی در فراوردههای پلاکتی تغلیظ شده از پلاسمای غنی از پلاکت
Background: Major platelet adhesive receptors that contribute significantly to thrombus formation include platelet receptor glycoprotein Ibα (GPIbα) of the GPIb-IX-V complex and platelet glycoprotein VI (GPVI). GPIbα plays a crucial role in platelet tethering to sub-endothelial matrix, which initiates thrombus formation at arterial shear rates, whereas GPVI is critically involved in platelets f...
متن کاملکاهش سطوح بیان رسپتور پلاکتی GPIbα بهواسطه ریزش خارج غشایی در فرآوردههای پلاکتی تغلیظ شده از پلاسمای غنی از پلاکت
Background: Platelet adhesion typically occurs by the critical role of GPIb-V-IX in capturing free-flowing platelets to the injured vessel wall where its rapid binding kinetics enables platelet tethering even under conditions of high shear through the interaction of the major ligand-binding subunit of GPIb-V-IX, GPIbα with subendothelial-bound vWF. During storage, platelet undesired activation ...
متن کاملاثر فرایند کاهش لکوسیتی پیش از ذخیره بر سطوح بیان مولکول پیش التهابی CD40L در فرآوردههای پلاکت رندوم حاصله از PRP
Background: Several lines of evidence suggest the role of leukocyte in platelet activation. Since pro-inflammatory mediator CD40 ligand (CD40L) has been considered as a marker of platelet activation that reflecting platelet storage lesion (PSL), we evaluated the effect of leukoreduction processes on thereby the levels of expressed CD40L in Platelet Concentrates (PCs). Methods: In present stu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Yale Journal of Biology and Medicine
دوره 48 شماره
صفحات -
تاریخ انتشار 1975